If you suffer from hand pain because of arthritis, a strained muscle, or another type of injury, then you can use Epsom salts to relieve the pain naturally. Although there is mostly only anecdotal evidence for its use in relieving pain, many say that it does work. The theory is that magnesium in Epsom salts helps to reduce inflammation and ease pain. You can make a soothing hand bath by filling a large tub of warm water. Then fill with enough water so that your hands are covered, and then add a cup of Epsom salts. Soak hands for 15 minutes.