It is also highly recommended that you moisturize your feet daily. A side effect of diabetes can cause the skin to dry out and crack as a result. As we know, Diabetics are prone to infection and even these cracks from dry skin can lead to a serious foot infection, and possibly even result in hospitalization. A good option to combat this side effect is to apply lotion daily. When using lotion, apply it specifically to the tops and bottom of the feet, but avoid getting any between the toes. If you do notice some moisturizer in these areas, you should wipe it away and dry between the toes very well.